THE NATIONAL
HEPATITIS C INSTITUTE

The Hepatitis C Awareness & Prevention Campaign


Serving the Hepatitis C Community

Immunoglobulins are used as starter material for many vaccines. Discribed as "protein molecules" produced in lymph tissue that are considered the "building blocks" for antibodies that aid the immune system in fighting infection and  disease.  The production of immunoglobulins begins with the Fractionation Procedure
Highlights from article: Hepatitis  C  Update
 
Immunoglobulins have been used in medicine for years to help prevent or reduce the risk of infections (for example serum immune globulin, Vaccinia,,Tetanus, Hepatitis B, Varicella Zoster immune globulin,  immune globulin, etc.).

In addition, anti-D immune globulin (Rhogam)... the fact that these immune globulin products come from pooled plasma where some donors probably carry transmissible infections. Click here Immunoglobulins transmit Hepatitis C and other bloodborne pathogens

Lawsuit Says Companies Sold Tainted Blood  
Cutter goes to trial J
Plaintiffs’ claims arise out of the most egregious misconduct in the history of the pharmaceutical industry, which resulted in the killing of thousands of hemophiliacs worldwide, with a continuing death rate of hundreds of victims per year. Defendants are American corporations which manufactured blood products ...sold these products to hemophiliacs worldwide, despite knowledge that the products were manufactured from sick, high risk donors and/or known to be contaminated with the viruses that cause AIDS and Hepatitis C (now known as HIV and HCV respectively). Defendants continued selling these products to hemophiliacs abroad even after the products were no longer being used in the United States due to the known risk of AIDS and Hepatitis C transmission. Plaintiffs are hemophiliacs from countries outside the United States who contracted HIV and/or Hepatitis C through use of Defendants’ contaminated products.


Immunoglobulin Transmits Hepatitis C. True or False?  
Intramuscular immunoglobulin preparations are prepared according to the Cohn fractionation process, which separates the fraction containing antibodies that neutralize various infectious agents. The resulting preparations are highly concentrated (16% in solution and containing 160 mg of protein/mL). Other manufacturing procedures do not ensure the same safety. 

The safety of HCV-RNA-positive Intramuscular immunoglobulin preparations can be attributed to several factors: 

(1) partitioning of viruses away from immunoglobulin, 

(2) inactivation of viruses by the fractionation process, and 

(3) a high concentration of neutralizing antibodies


  • 1995 Philadelphia Inquirer
    final Section: EDITORIAL REVIEW & OPINION Page: E01 SUNDAY April 16, It is one of the little-known stories of World War II. Had more attention been paid to it, hemophiliacs in the United States might not be dying now at the rate of one a day. It was 1944, five years into the war

     

  • 1969 New York Times Washington, July 28 -- that gross contamination was apparent in the areas where the largest blood plasma operations were conducted. The rooms were "sloppy," he observed...The gamma globulin from most donors contains enough antibodies against such diseases as measles and hepatitis to be effective when it is reinjected into a person who has been exposed to those diseases. ....Groups of donors receive vaccinations to build up the antibodies in the gamma globulin intended to treat these illnesses. The result is known as hyperimmune gamma globulin ........... By April, 1963, five months after Dr. Stough had opened his plasmapheresis center at Kilby, the incidence of viral hepatitis an often fatal disease of the liver, was climbing sharply. ................At Kilby, for example, 28 per cent of the men who participated in Dr. Stough's program came down with the disease. For those who did not take part, the rate was only 1 percent. 

 


1999 - Benefits and risks due to animal serum used in cell culture production. 
The use of contaminated cells for vacc
ine production may result in contaminated vaccines, which may lead to seroconversion or disease in the vaccinated animal. Contaminated serum or cell cultures may also interfere with the diagnosis of viral infections. PMID: 10404869

Although the public has heard about side effects of vaccines, most people are clueless about the manufacture of vaccines. Few people know that viruses used in vaccine production need to be grown on animal parts like monkey kidneys, or in chicken embryos, or in human and fetal “cell lines.” Harvesting viruses in human cell-lines can be perilous because some human cell lines are derived from cancer cells. Most people assume vaccines are “sterile” and germ free. But sterilizing a vaccine can destroy the necessary immunizing protein that makes it work. Thus, contaminating viruses or viral “particles” can sometime survive the vaccine process. Vaccine Dangers

In the mid 1990’s, there were reports of Hepatitis C transmission following the administration of some brands of serum immune globulin. ....this underscores the importance of having a clear indication for the use of these products. Read more:

Study Outbreak of Hepatitis C Associated with Intravenous Immunoglobulin Administration —
United States, October 1993–June 1994

  • Three generations of immunoglobulin  
    1986
    The first purified human immunoglobulin G (IgG) preparation used clinically was immune serum globulin (ISG), which was prepared in the 1940s by E. J. Cohn's group. It was originally formulated in water with 0.3 M glycine at pH 6.8 and was 70%-80% monomeric.


  • INTRAVENOUS (HUMAN) Rho(D) IMMUNE GLOBULIN
    For transfusion related sensitization, treatment is recommended for Rh-negative children and women of childbearing age who received Rh-positive red cell containing components


  • Did the Shots Cause HCV  
    "Intramuscular immune globulin is safe and has never transmitted hepatitis C or any other infectious disease as licensed in the United States," said Miriam Alter, the CDC's chief hepatitis epidemiologist. 


  • Hepatitis C Origin  
    Points to Possible Military Link Copyright 1999 by Forward Times- DOCUMENTS RAISE QUESTIONS ABOUT VIETNAM ERA EXPERIMENTS ED WENDT-Documents obtained by Forward Times under the Freedom of Information Act, for an investigation of the hepatitis C epidemic, reveal that U.S. servicemen were used to test experimental vaccines while they were in Basic Combat Training during the Vietnam Era” “ blood samples of American servicemen taken in 1948 were recently reviewed during a study. Those samples detected the hepatitis C virus.”


  •  Citizens Against Legal Loopholes  
    A Speech Before the Citizens Against Legal Loopholes Rally
    , The Capitol Mall, Washington, D.C., Labor Day Weekend, 1996 By Leonard G. Horowitz,  "So I began by investigating the Centers for Disease Control and Prevention's (CDCs) official investigation reports on the case. ..reports to be scientifically bogus. ... government had covered-up key evidence in the tragedy in an effort the maintain the case an unsolvable mystery.... committed scientific fraud and misconduct .....


  • EMERGING VIRUSES  
    1996 by Leonard G. Horowitz  AIDS & EBOLA: Nature, Accident or Intentional" Tetrahedron Inc. Rockport, MA . Foreword written by  W. John Martin, M.D., Ph.D.  The mixing of vaccine viruses with others found in the cells and tissues used to develop the vaccine can potentially lead to the development of new recombinant mutants that are more adaptive and have wider host range than either of the original viruses. This can especially happen when a live viral vaccine produced in cells from one species is then given to another species.  


  • MORATORIUM ON VACCINES  
    THE SAN FRANCISCO MEDICAL RESEARCH FOUNDATION
    Food and Drug Administration (FDA) officials, in charge of testing and approving vaccines for drug makers, have known of these contamination problems since the early 1970s”


  • MATILDE KRIM'S AIDS-ORIGINS-THEORY  
    Krim speculated that AIDS could have originated from virus-contaminated batches of "gamma globulin" which were inoculated into gay men for the purpose of protecting them from hepatitis virus inflection. Krim is a well-known AIDS expert and cancer virologist associated with Sloan-Kettering Hospital in Manhattan. She is also co-chairperson of the American Foundation for AIDS Research (AmFar).